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吴宗宪发言再爆争议，他日前在节目《综艺大热门》中，表示忧郁症患者都是因为“不知足”，引发网友不满出征粉专留言抨击“你真的不懂得闭嘴”、“阿不就很知足”！

当时《综艺大热门》节目中来宾李明川表示，自己之前有失眠和忧郁症，后来用花艺疗愈自己，也希望用花艺去疗愈大家，吴宗宪接口说道：“你干嘛忧郁症呢？我跟你讲，3个字，所有忧郁症的患者仔细听着，忧郁症的原因都是因为这3个字，你理解了以后，你就过关了，都是因为，听好了、站好，都是因为‘不知足’，生命当中你要想的是拥有的而不是失去的，对不对。”

许多网友则到吴宗宪粉专留言“原来忧郁症是因为不知足喔。受教了”、“忧郁症是疾病！那老人痴呆你是不是要叫他记清楚点就好”、“身为一个忧郁症患者，你这人渣”、“要知足不要去中国赚钱R”、“你心里是不是认为主持节目就是要固定得罪某群人”、“你要污名化忧郁症患者前有没有去做过功课？难道要跟你一样的所作所为才是知足吗？我是忧郁症患者，但我有一个老婆就很知足，不像某人！”

对于网友批评，吴宗宪不满表示：你们有看过整集节目吗？以媒体的角度当然是激化对立对你们最有利，所以这世界上就没有公理正义了，尤其是你们最喜欢断章取义！”他解释节目原意是鼓励忧郁症病人往正面看，珍惜自己拥有的，不要只往负面想，呼吁大家不要曲解他。（台湾苹果日报报道）