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武汉市新型冠状病毒感染的肺炎疫情防控指挥部周四凌晨宣布，为有效切断病毒传播途径，由周四上午10时起全市的公共交通及长途客运暂停营运，机场及火车站的离境通道亦暂时关闭，直至另行通知。无特殊原因，武汉市民被要求不要离开武汉。

消息公布后，武汉高铁站出现排队人龙，大部分都要求改签车票，希望赶及在离境通道关闭前离开。

武汉高铁站不少乘客拖着行李箱，急步走向自动售票机，希望买到最早班次的车票离开，而有预购了高铁票的乘客也赶到东广场的通宵票务处改签。由于人数众多，现场一度混乱，站方其后派出保安维持秩序。

区交通大队的民警及区卫健局的工作人员也已对进出武汉车辆及人员进行疫情排查防控，出城者要接受体温检测，同时对进城车辆所搭载动物进行检查，严禁野生动物进入武汉。

世卫官员认为，武汉当局的做法是要防止病毒传播和群众聚集，并非不寻常。

有当地居民在微博写道：“一觉醒来，武汉封城了，说不恐慌，不害怕是假，五点多出院门，准备出去买点啥，药店没开门，大街上空荡荡的，只有环卫工在扫大街。”

截至周四凌晨12时，全中国增至571人确诊，死亡人数累计17人；江苏及黑龙江亦出现当地首宗确诊病例。