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胰脏发炎通常是胆道或胆管疾病引起，饮酒过量的问题也不少，代谢改变三酸甘油酯过高、医疗行为、药物疾病都有可能。

担任业务工作的小唐，为了求得好表现免不了得经常交际应酬，最近和朋友聚餐时，几顿大鱼大肉加上烟酒不忌，这天他正准备回家的时候，突然上腹部严重疼痛，整个肚脐周围痛到不得了，本想说躺下来休息一下就会好，没想到平躺情况更糟，除了肚子疼痛难耐之外，又出现恶心、想吐症状，同事一看事态严重，赶快将他送到医院，经过检查确定是急性胰脏炎发作。

在诊间因为急诊前来求助的都是急性胰脏炎！上述例子中的小唐，就是典型急性胰脏炎个案。病人会明显且长时间在上腹部剧烈疼痛，有人甚至还会辐射至整个后背部疼痛，这必须视病人病变的位置而定，发作多是突发且持续性的，不会因为病人休息或是变换动作而减轻疼痛程度。

胰脏发炎的疼痛感和溃疡性穿孔及肠堵塞等痛的方式不同，而且透过触诊和X光检查，轻易就能分辨。有些胰脏发炎病人还会出现恶心、呕吐、腹胀，甚至伴随有发烧、心搏加速、呼吸短促等，发作时有一定的危险性，不可轻忽。