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要提防膝痛发作，可透过改善或留意生活细节预防。膝痛病人不宜长期坐矮凳、矮梳化或进行蹲下的动作，因为过度屈膝会增加关节压力。日常宜减少长时间站立或步行，若无可避免可使用拐杖，要提取重物时可用手推车。

不少膝痛病人使用护膝，长期使用护膝会造成依赖，令肌肉变弱甚至萎缩，导致膝关节失去保护能力。在急性发作的日子，一般建议每日最多用2至3小时，例如在需要长时间站立或走路的时段，有疑问最好咨询物理治疗师意见。

受膝痛困扰的主妇，煮饭时双脚可轮流踩矮凳，减少膝部劳损。一些简单的入厨工序如切菜不妨转移到客厅坐着进行，减少长时间站立。如日常长时间留在家中做家务，可穿着有一定厚度的拖鞋作承托，避免穿薄底拖鞋。

若遇上膝痛急性发作，即有红肿热痛症状，可冰敷15分钟纾缓痛楚。如膝痛时只有疼痛及僵硬感，没有红肿及发热，则属于慢性痛症，可尝试热敷作改善。