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非洲猪瘟去年肆虐中国，中国农业科学院去年9月宣布疫苗将进入临床试验阶段，至日前终发表论文，声称研究证明一只健康小猪的原代细胞能制备出至少20万份疫苗，完全具备大规模生产的条件，亦是目前最具实现产业化应用前景的疫苗，将为防控非洲猪瘟疫情提供重要的技术手段。

哈尔滨兽医研究所发表论文，指研究人员以中国第一株非洲猪瘟病毒分离株为骨架，构建一系列具有不同基因缺失的重组病毒。通过在猪体内进行致病性、免疫原性和免疫保护性试验，遴选出一株具有7个基因缺失的病毒，符合弱毒活疫苗安全性标准，有效提供免疫保护。

据了解，国际上曾有相关研究，但猪只均产生较高程度的病毒血症，体内持续带毒时间长，毒力返强风险高，安全性方面距离产业化应用存较大差距，而此次的疫苗接种在猪只身上后，仅在部分淋巴结内有限复制，大约2周就被自身彻底清除，无法持续体内连续传代，不存在毒力返强风险。

另该疫苗对怀孕母猪具良好的安全性，接种后不会流产，免疫后分娩的小猪健康率与未免疫对照组没有区别。

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