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【武汉肺炎】李兰娟团队公布 2药物有效抑制病毒

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李兰娟公布最新研究成果。

中国国家卫健委高级别专家组成员李兰娟,日前率队前往新型冠状病毒肺炎重灾区湖北省武汉市提供协助,她周二公布最新研究成果,称发现有2种药物能有效抑制病毒,效果分别为对照组的60倍及280倍。

阿比朵尔。

她说,根据在体外细胞实验,初步测试显示抗病毒药物阿比朵尔(Arbidol)在10μM至30μM的浓度下,与未使用药物的对照组比较,能有效抑制新型冠状病毒达60倍,并且显着抑制病毒对细胞的病变效应。另一种药物达鲁那韦(Darunavir)在300μM的浓度下,能显着抑制病毒复制,与对照组比较,抑制效率达280倍。

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达鲁那韦。

据了解,阿比朵尔,其主要适应症为甲型及乙型流感病毒引发的流行性感冒,同时亦对其他呼吸道病毒感染有机会有抗病毒活性。至于瑞士杨森制药的达鲁那韦则是一种治疗爱滋病的药物,是被世卫认定最安全、最有效的基本药物之一。

李兰娟表示,建议将上述2种药物列入中国国家卫健委的诊疗方案中,并称实际上另一种治疗爱滋病的药物克力芝(Kaletra),其治疗新型冠状病毒肺炎的效果不佳,且有毒性副作用。

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李兰娟的团队成员,浙江大学医学院附属第一医院副院长陈作兵亦称,阿比朵尔及达鲁那韦已经在浙江用作治疗新型冠状病毒肺炎患者,下一步计划会以此替代其他效果欠佳的药物。但他提醒,阿比朵尔及达鲁那韦均为医生处方药物,患者必须要在医生的指导下服药。

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