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欧美指控伊朗防空导弹系统意外击落乌克兰国际航空公司客机。事件反映民航机在战区飞行的安全问题，而过往亦曾有客机遭导弹击落，包括2014年马来西亚航空公司MH17客机，在乌克兰东部战区上空，遭俄罗斯导弹击落，全机无人生还。

2014年7月17日，马航MH17客机从荷兰阿姆斯特丹飞往马来西亚吉隆坡，在靠近俄罗斯边境的乌克兰东部领空解体坠毁，机上283名乘客及15名机组成员全部罹难。

这是民航机遭导弹击落，死亡人数最多的空难事件。以荷兰当局为首的调查团调查显示，客机遭亲俄叛军的俄制导弹击落，但俄罗斯否认相关结论。

1988年7月3日两伊战争期间，伊朗航空IR655空中巴士A300客机，由伊朗阿巴斯港飞往阿联酋杜拜时，在伊朗水域被美国海军神盾巡洋舰“文森斯”号发射导弹击落，机上290名乘客及机组人员全部罹难。

当时美国政府辩称军舰当时误认该客机为正执行攻击任务的伊朗F14战机。