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789
今届医学奖由(左起)西门扎、拉特克利夫及凯林共同夺得。
2019年的诺贝尔生理学或医学奖,周一(7日)率先在瑞典揭晓,由美国癌症学家凯林、英国医学家拉特克利夫及美国医学家西门扎共享殊荣,表扬他们对细胞如何感知及适应氧气供应研究的贡献,对治疗贫血、癌症等疾病有关键作用。
诺贝尔委员会指,人类早于多个世纪前已知悉氧气的重要性,动物需要氧气,将食品转化成有用的能量,但科学家对细胞如何适应氧气减少或增加的情况一直并不了解。
得奖的3名科学家发现细胞如何检测到体内氧气增减并作出应对,找出分子机制调节基因活动,以应对不同程度的氧气含量;3人亦发现氧气含量如何影响细胞新陈代谢和身体机能,为治疗贫血、癌症和其他疾病起关键作用。评审指出因为他们的发现,学术实验室和药厂都在致力研发药物,透过启动或封锁感知氧气的细胞机制,而治疗达致不同严重程度的疾病。
其中于美国约翰斯霍普金斯大学任职细胞工程学教授的西门扎,发现HIF-1(缺氧诱导因子-1)所调控的基因能够作用于线粒体呼吸,它能够指导细胞对缺氧状况的特殊反应和心血管系统的变化。
诺贝尔委员会秘书长于公布结果前致电得奖者通报喜讯。
诺贝尔委员会秘书长成功联络3名得奖人,其中凯林和拉特克利夫对获奖表示高兴。3名得奖者将可平分900万瑞典克朗(约383万令吉)奖金,金额与上届相同。
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